Scientists may have produced the strongest evidence so far that the logical impermissibility vaccine is associated with a decrease in the risk of dementia.
Using healthy records of more than 280,000 older adults in Wales, researchers have found those who received a 20 percent less likely to develop developer to develop dementia over the next seven years than those who did not receive the vaccine.
Results, It was published on Wednesday in the journal Nature, and constructed on other recent studies that have shown connections between herpes virus infections and an increase in the risk of dementia.
The main author Pascal Gildesitzer, From Stanford University, he said that the preventive effects of the vaccine seem “much larger” than those offered by current dementia, but more research was needed to determine whether the noticeable effects were really causal.
“If the logic vaccine is truly prohibited or delayed dementia, then this will be a very important discovery of clinical medicine, the health of the population and the research in the causes of dementia,” said Gildesitzer.
According to researchers, there are two potential mechanisms that may explain how the logical impermissibility can reduce the danger of dementia, and they are You may even work together.
The first is that vaccination reduces the reshaping of the sleeping virus, which has been proven to cause long -term cognitive weakness and brain diseases similar to what appears in Alzheimer’s disease.
The virus of the foolish, which is a type of herpes virus, causes water to be chopped and can remain in the body for years, and is reinforced later as a method.
“There is an increasing set of research that shows that viruses that target preferentially the nervous system and hibernation in your nervous system in most of your life may be involved in the development of dementia.”
The RiverView Health Center, which is the Winypeeg Hospital, has created a long -term patient, as patients with Alzheimer’s and dementia are recovered with things of their past, such as an antique salon hair dryer and a desktop with an archaeological writer. They also have a sensory room, carpentry store and nursery.
The second possible mechanism is that vaccination leads to a more prevalent immune response.
The study was a “prominent discovery” in brain health and disease prevention.
“It supports the emerging understanding that infections-especially viruses such as foolish-zostre-can contribute to the long-term nervous decline.”
Natural “genius” experience
While other studies looked at the relationship between logical imbalances and the danger of dementia, it was difficult for researchers to separate the effects of the vaccine from the effects of other variables such as diet and exercise, which could also affect the danger of dementia.
The spheres with evidence is the golden standard for the study of causal relationships and can help get rid of these biases, but they are exceptionally expensive and density of resources, especially throughout these long periods.
To overcome this, geldSetzer and his colleagues Depend on a large “natural” experience that can help them answer the question in a similar way to a random experience.
In 2013, Wales launched the logic vaccine for the older adults. But the stranger initially means that those who were seventeen years old on September 1, 2013 were eligible to receive the vaccine for at least one year, while those who reached 80 years were not qualified for life.
“Just a one -week difference during this disposal of the date of birth means that you do not move from anyone who is vaccinated to about half of the inhaled population,” said Gilsitzer.
Thanks to electronic health records at the country level, Researchers can Look at almost all Wales residents born between September 1925 and September 1942 to find out how the vaccine has affected the danger of dementia.
They focused their analysis on the closest people next to the threshold of the vaccine eligibility, so they were as close as the same as possible.
Those who received the logical imbalance vaccine were 3.5 percent less likely to get dementia in general, and the lowest possibility of 20 percent of those who were not vaccinated.
“It was a truly great discovery,” said Gildesitzer.
The research team has also investigated the impact of other variables, such as education levels and other common health conditions rates, via both dust.
But they were unable to find any differences, regardless of the vaccination, would explain the amazing decrease in dementia diagnoses.
“It is a genius use of records of records and connection,” said Perminer SACHDEV, a nervous psychiatrist who focuses on dementia and did not participate in the study.
“It is an example of the power of electronic records at the country level and the ability of researchers to link various health data groups.”
The researchers also found similar results in a second population, using electronic health records and death of dementia from England.
Study the benefits of the vaccine
While the results, if you are confirmed through more research, the proposed vaccination can be an effective tool to prevent or delay dementia, as they raised many questions.
To start, the study found that the danger of dementia has decreased significantly in women more than men.
This is not a unique discovery of this study; Other studies on logic vaccination and the danger of dementia I also found that women seem to benefit from the vaccine more than men.
“We know that the effects of vaccines are stronger in women, and that the immune responses of vaccines differ in men and women.”
“We need to know more, including (about) sexual differences in causing dementia in general.”
More studies were also needed to understand how vaccination could give protection against dementia.
The research team specifically looked at the herpes vaccine – known as Zostavax – which was usually used at the time.
CanadaThe United Kingdom, the United States and Australia are currently Everyone recommends a different vaccine called Shingrix, which uses a different technique, which is much more effective in protecting from shingles.
“There was evidence for some time that the elderly who receive their vaccines in general are less likely to develop dementia. This is the best evidence that this does not appear yet,” said Henry Broadati, co -director of the ONSW brain aging center who did not participate in the study.
“Future research will determine whether the Xingarx will not be the most newest vaccine will provide the same benefit and whether the fortunes in the younger ages may be in the same way.”
big The American study was published last year I found that Singrix seems to reduce the risk of dementia beyond Zostavax.
However, researchers in the current study believe that the living nature of the Zostavax vaccine may have specific benefits to reduce dementia risks, and hopes to finance more clinical trials achieved in it.
Although there is no confirmation of dementia, doctors also recommend other steps of proper charging to reduce risk. Social and active survival. And control of high blood pressure, and for people with diabetes, blood sugar rises, both of which are linked to cognitive decrease.
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