Perhaps scientists have discovered the cause of young colon and rectal cancer often

The common bacteria in our intestine may raise a greater problem than we knew. A study outside this week found evidence that tuccin for the mutations produced by some breeds Escherichia coli It can lead early at the beginning of colon and rectum cancer.

Scientists at the University of California San Diego led the research, Published Wednesday in nature. They found a link between exposure to toxins, called Colibactin, and colon and rectal cancer are more likely to occur among young people. Researchers say the results can help clarify the reason for the high rate of colon and rectal cancer early in mysterious circumstances in recent years, although more research is needed to confirm a causal connection.

Colon and rectal cancer is the fourth most common cancer, with approximately 150,000 Americans every year. It is also the second most important cause of death, killing about 50,000 Americans annually.

As with many types of cancer, the incidence rate and the death rate for colon and rectal cancer decreased steadily over time. However, this decrease is not distributed evenly, as colon and rectal cancer is increasing in young and medium adults. According to the American Cancer Society, colon and rectal cancer rates are among people under the age of 50 more 2.4 % per year between 2012 and 2021.

Scientists are not sure why these cancers have become more common in the younger Americans, although some research referred to the finger. Manufactured foods, high obesity rates and other lifestyles. But this new study seems to add another suspect.

The researchers in the study were not specifically looking to reveal this puzzle; They were more interested in understanding the reason for some parts of the world at higher rates of colon and rectum more than others. To do this, they analyzed the genetic signature of colon and rectal cancer taken from about 1,000 people around the world. These samples included people with early and early cancer.

Colibactin is already known to cause mutations in our cells that can provoke the risk of cancer, and have been linked to previous colon and rectal cancer. But the researchers were surprised when it found that chulactine’s mutations were more than three times more common in the early appearance cancers they studied compared to late appearance. They also found molecular evidence that these cholkin mutations tend to appear early in the development of the tumor, indicating that they play a vital role in fueling these cancers.

In addition to other research that shows that chulactin mutations often appear in the first ten years of life, the authors argue that this poison can be a major incitement to colon and rectum cancer at first.

“These mutation patterns are a type of historical record in the genome, and indicate early life exposure to collabactein as a driving force behind early sidewalk diseases,” said the prominent study author of Woodmil Alexandrov, researchers who specialize in California University of California, San Diego in A. statement From the university.

Researchers note that Colibactin may only be a large large piece of the larger puzzle. Note that cholectine -related mutations are rarely found in more rural parts of the world. So it is possible that other environmental factors such as diet or the use of antibiotics are likely to encourage Colbactein’s growth Cola Bacteria in the intestine in places such as the United States outside the colors are two, there may be other exposure that can explain the high rates of cancer in various countries.

But the team’s results provide fertile floor for future research, and may even lead to interventions that can slow down or reflect the high colon and rectum cancer in the beginning. The researchers already hope to study whether probiotics may be able to get rid of these damages Cola Stains, they are trying to develop early detection tests that can examine the mutations related to cholctin.

All this work, however, depends on more funding. The researchers soon notice that the United States government is under President Donald Trump’s leadership Strongly limited financing One of the national health institutes in recent months – the same type of financing that may go to important cancer research like their devices.

“If the national health institutes financing discounts affect our ability to do this work, then, in my opinion, it will be a major blow to cancer research not only in the United States, but at the global level,” Alexandrov said. “Our financing allowed us to cooperate with cancer researchers all over the world, and collect and analyze large data groups of patient samples in multiple countries. This type of size is what makes discoveries like this possible.”