This new substance may one day be prevented from severe inflammatory reactions such as Irritable Bowel Syndrome and asthma

Bastly cells It is part of our immune system, protecting our bodies from viruses, bacteria and even harmful substances issued by the snake and meat. When alerting to the presence of these invaders, mast cells can create mucus, stimulate swelling and itching, and make the muscles a shrinkage in the air, stomach and intestine. While these symptoms allow the body to destroy or expel the invaders, the allergic allergic cells cause allergic reactions, including life -threatening conditions that are difficult to treat.

As is detailed in a Ticket It was published on Monday in the magazine of transmitting a signal and targeted treatment, and the researchers have developed a boat that prevents obese cells from moving to sometimes life -threatening reactions. These include irritable bowel syndrome (IBS), asthma, chronic itching, and migraines. Traditionally, false reactions are allergic, and these conditions have been classified recently as a kind of allergy, according to researchers. The compound appears to reduce symptoms, and as a result, the risk of death is low.

“We see this is a very promising substance,” said Christa Muller, the co -author of the study looking for the medical chemistry of the membrane proteins at Bonn University. statement.

Unlike some allergic reactions, which are called immune cells called antibodies, the mast cells are alert to the presence of invaders, these conditions that are difficult to treat when the mast cells are operated through direct activity that does not involve antibodies. Muller explained that this raises the reactions “of a specific nature that is difficult to treat, and remains to this day.”

15 years ago, Muller and his colleagues have set a future called MRGPRX2 in the membrane membrane, which “operates” these types of reactions when these species are Certain particles We comment on it. “To prevent this reaction, the key must be banned in one way or another,” Muller continued. “The question was: How?”

To address this, the team tested promising vehicles of a group of 40,000 pre -collected by the Muller section. “We have used the cells that illuminate when stimulating MRGPRX2, so we can then test whether the materials prevent the effective activation of the future, and the closure of light signal,” explained the yellow spinning, a doctorate student in Muller and the first author of the study. In this way, the team discovered a molecule that can link it with and ban receptors, which leads to an effective turning off.

They used this molecule to develop a substance that still works in very low doses, and has proven effective in eliminating life -threatening allergic reactions in laboratory mice and prohibiting MRGPRX2 receptors on isolated human bastard. They also claimed that the molecule prevents only intended receptors, which avoids the risk of side effects.

While Al -Hamwi, Muller and their colleagues have improved the effectiveness and duration of the material, more experiments should be done on animals and eventually before approval and marketing it as a drug. However, it carries possible effects to save life for patients who suffer from some inflammatory and those at risk of allergic shock.