Some fungal diseases in humans no longer respond to medications, which increases the risk of severe disease and death, as well as the spread of the disease, according to a new report.
Tuesday, Global Health Organization (From) Publishing what it calls its first report at all about the lack of tests and treatments for fungal infection.
Yeasts, molds and mushrooms are all examples of fungi. Common nail infections or common vaginal yeast infections and can be treated, but this is not always the case.
“Fungal diseases are an increased concern for public health, with common infections – such as candidiasis, which cause oral and vaginal castles – grow increasingly for treatment,” said treatment.
Here are some of the main things to know about fungal diseases in Canada and around the world.
What are fungal diseases and why do you care?
Fungal diseases are a type of infectious disease that spreads from person to person, such as touching a person who has infection or sharing clothes with them, or in an environment, such as breathing in germs.
Jerry Wright, a professor of biochemistry, says the reports of the World Health Organization are drawing attention to an important problem.
“We all have someone in our lives know how he was touched by cancer, making it weak, or who have kidney transplant or heart transplant or who has lupus,” said Wright, who is looking for new ways to kill fungal pathogens at McMaster University in Hamilton.
He says all of these cases are dealing with immunosuppressive-people-and people with weak immune system are more likely to fungal diseases.
Invasive fungal diseases are when fungi enter the blood, tissues and other places in the body, which are usually sterile.
The death rates said in a statement that for fungi in the category of “critical priority”, the World Health Organization, death rates of 88 percent.
The deadly fungi – known for causing a potential killer disease called the valley fever – is lying in the southwestern soil of the United States, it is not yet in Canada, but thanks to climate change, it moves north.
“You can get lung infections, so fungal pneumonia,” Wright said. “There are even certain types of fungi that have a rapprochement of the nervous system so that you can grow in the spinal cord and in the brain. What place you think about it will be a bad place for an infectious object, fungi can make its way there.”
What is new?
He said that the best treatments for diseases such as cancer means that more people suffer from the conditions that immunity offer, which may also mean increases in cases of invasive fungal diseases.
Rebecca Shapiro, associate professor studying fungi at the University of Gilf, pointed to some other factors behind the increasing rates.
“We have seen an increase in fungal infections, especially there was a lot of Subscriber From fungal diseases during Covid-19 She said, “People with very patients and hospitalized with Kovid were also very vulnerable to fungal diseases.”
While about ten categories of antibiotics are available to treat bacterial infections, there are only three main categories of antifungal.
“We also have to be concerned about how we use fungi anti -fungi in the clinic and also in agriculture,” Shapiro said.
They are sprayed on crops to prevent mold, scourge and rust diseases.
“One of the problems seems to be that there is not much communication regarding how drugs are used on both sides.”
Take the sex of aspergillus, for example, which is common in the environment. but Aspergillus Fumigatus Types cause a variety of diseases, from allergies to gaseous machine guns, a serious fungal infection, depending on the condition of a person and lung immunity. This particular infection is increasingly resistant to fungal antibiotics due to use in both the clinic and in agriculture, which is called “worrying”.
To help combat this, doctors encourage patients on End the entire session From antifungal therapy. Correctly getting rid of medications prevents antifungals from entering the environment, as microbes may also develop resistance.
What is the situation in Canada?
Candida Oris It is the causes of other fungi that the World Health Organization called a critical priority. Yeast shape is easily spread in hospitals and long -term care homes, especially among people with weak immune system. It may be difficult to treat successfully when the bloodstream is invaded and often resistant to antifungal drugs.
As of March 26, a total of 65 cases of C. Auris have been reported throughout the country since 2012, when the first case was identified, the Public Health Agency in Canada said. Of these cases, 46 has been identified since 2019.
“The C. Auris can be a multi -drug resistance, which means that it is not affected by at least two types of antifungals,” the federal agency said in an email. “All the cases known in Canada so far have responded to at least one Recommended treatments“
Most fungal pathogens grow on the skin, which have a cooler temperature than inside the body.
Wright said that C. Auris is an exception.
What next?
Who said that antifungal drugs that work against a wide range of severe infections are required, and children are particularly deprived. The organization said that there are sufficient credit treatments. Over the past decade, only four new matches have been approved in the United States, the European Union or China. Of the nine of clinical development, there are only three in the last stage, which means that there are a few expected approvals in the next decade.
She said that the drugs currently available can have serious side effects and require long hospital accommodation.
Both Wright and Cabero laboratories are developing potential antifungals.
“There is really a group of people who understand this is a big problem and work to try to solve it,” Wright said. “But you know, we have no solutions overnight.”
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